Immunoglobulin therapy - Tissue - Deceased Donors

Essential information

Obligatory

Must not donate if:

Immunosuppressed.

Donors with recovered immunodeficiency:

Refer to a Designated Clinical Support Officer.

Discretionary

1. If the intravenous or subcutaneous human immunoglobulin was given before 1980, accept.
2. Routine ante- and post-natal use of anti-D immunoglobulin, accept.
3. If single dose prophylactic immunoglobulin has been given, accept.
4. If treated with intravenous immunoglobulins after 01 January 1999:
   If underlying condition is not a contraindication, accept.
   Refer to Designated Clinical Support Officer if further advice required.

Supporting information

See if relevant

• Hepatitis A
• Hepatitis B
• Rabies
• Tetanus immunisation

If treated with intravenous or subcutaneous human immunoglobulin:

• Transfusion

Additional information

Immunoglobulin used before 1980 is unlikely to be affected by vCJD.

Single dose immunoglobulin is unlikely to pose a significant risk for transmitting vCJD.

Since 1999, intravenous immunoglobulins prepared from UK donors have no longer been used, as a risk reduction measure for vCJD transmission.

Reason for change:

To permit donation from donors who have received intravenous immunoglobulin after 1st January 1999, if the reason for treatment is not a contraindication.

Version details:

TD-DSG Edition 203 Release 45 (11 May 2021)