Nomenclature - Granulocyte immunology - Chapter 17

The current HNA nomenclature is based on epitopes and allelic typing and this must be used for recording granulocyte-specific alloantigen and alloantibody specificities [Flesch, 2016]. Details of nomenclature for HNA alleles, epitopes and corresponding antibodies are shown in Tables 17.1.1 to 17.1.5.

Table 17.1.1: Current HNA nomenclature – HNA-1 system
Allele Epitopes Original name Glycoprotein CD

FCGR3B*01

 HNA-1a

NA1

FcγRIIIb

 CD16

FCGR3B*02

 HNA-1b, HNA-1d

NA2

FcγRIIIb

 CD16

FCGR3B*03

 HNA-1b, HNA-1c

SH

FcγRIIIb

 CD16

FCGR3B*04

 HNA-1a

n/a

FcγRIIIb

 CD16

FCGR3B*05

 HNA-1bv (†)

n/a

FcγRIIIb

 CD16

Notes on Table 17.1.1

(†) ‘v’ indicates a variant epitope that may have different serological characteristics with some antisera.

Table 17.1.2: Current HNA nomenclature – HNA-2 system
Allele Epitopes Original name Glycoprotein CD

Unknown

 HNA-2

NB1

GP56-64kDa

 CD177
Table 17.1.3: Current HNA nomenclature – HNA-3 system
Allele Epitopes Original name Glycoprotein CD

SLC44A2*01

 HNA-3a

5b

CTL-2

 n/a

SLC44A2*02

 HNA-3b

5a

CTL-2

 n/a

SLC44A2*03

 HNA-3av (†)

n/a

CTL-2

 n/a

Notes on Table 17.1.3

(†) ‘v’ indicates a variant epitope that may have different serological characteristics with some antisera.

Table 17.1.4: Current HNA nomenclature – HNA-4 system
Allele Epitopes Original name Glycoprotein CD

ITGAM*01

 HNA-4a

MARTa

CD11/18

 CD11b

ITGAM*02

 HNA-4bw (†)

n/a

CD11/18

 CD11b

Notes on Table 17.1.4

(†) ‘w’ indicates a workshop designation – no antibodies against this epitope have currently been described.

Table 17.1.5: Current HNA nomenclature – HNA-5 system
Allele Epitopes Original name Glycoprotein CD

ITGAL*01

 HNA-5a

ONDa

CD11/18

 CD11a

ITGAL*01

 HNA-5bw (†)

n/a

CD11/18

 CD11a

Notes on Table 17.1.5

(†) ‘w’ indicates a workshop designation – no antibodies against this epitope have currently been described.

References

Flesch BK, Curtis BR, de Haas M, Lucas G, Sachs UJ (2016). Update on the nomenclature of human neutrophil antigens and alleles. Transfusion, 56, 1477–1479.