Tissue and cell allograft recipients - Bone Marrow and Peripheral Blood Stem Cell

Essential information

Excludes

Xenograft recipients, recipients of biological grafts of non-human origin and bio-prosthetic grafts, organ recipients.

Obligatory

All donors:

Must not donate if:

  1. Dura mater transplanted at any time.
  2. Ocular tissue transplanted at any time.
  3. Any other allogeneic human tissue or cell transplanted since 01 January 1980, refer to DCSO.
Discretionary
  1. If an autologous tissue, or cells, has been transplanted at any time, and there is no other reason to exclude the donor, accept.
  2. If an allogeneic tissue (except dura mater or ocular tissue) or cell transplant was performed before 01 January 1980, and there is no other reason to exclude the donor, accept.

Supporting information

See if relevant
Additional information

The transfer of tissues or cells between individuals has led to the spread of infection. The above guidelines are intended to minimise these risks.

People who have received a tissue or cell transplant since 1980 are normally excluded from donation as a precautionary measure against the risk of transmission of vCJD in the same way as recipients of transfusion are.

The DCSO should consider the availability of alternative donors and discuss the risks and benefits with the physician of the intended recipient. This risk assessment should be shared with the recipient, or their next of kin as appropriate

Dura mater and ocular tissue allografts have been implicated in iatrogenic CJD. Iatrogenic CJD refers to the transmission of prions via inadvertent medical exposure. Recipients of dura mater and ocular tissue recipients are excluded.

Dura mater use stopped in the UK by 1993. The situation in other countries varied so specific dates cannot be given.

Reason for change:
This is a new entry.
Version details:

BM-DSG Edition 203 Release 51 (04 July 2023)