Hepatitis of unknown origin - Bone Marrow and Peripheral Blood Stem Cell
Scenarios
Affected individual
- Includes
- Excludes
- Obligatory
Must not donate if:
Less than 24 months from recovery.
- Discretionary
- If more than 12 months, but less than 24 months from recovery, obtain history and blood samples and refer to a Designated Medical Officer.
- If more than 24 months from recovery, accept.
- Additional information
If more than 12 months and less than 24 months from recovery:
- If negative for all markers of hepatitis B, accept.
- If HB core antibody is positive and HBsAg is negative and HBV-DNA is negative, accept.
Sexual partners of affected individuals
- Includes
- Excludes
- Obligatory
Must not donate if:
Less than 12 months from recovery of partner.
Person sharing a home
- Includes
- Excludes
- Obligatory
Must not donate if:
Less than 12 months from recovery of the last affected person in the home.
- See if relevant
- Sexual partner of affected individuals above
- Additional information
Most hepatitis of unknown origin will have been due to hepatitis A or hepatitis E (or non-viral causes). Additional testing for those who give a history of hepatitis between 12 and 24 months before donation will exclude the rare case of HBV which may have delayed clearance of infection and therefore will still present a risk through donation.
- Reason for change:
- Clarification regarding hepatitis B markers has been added to the additional information. To remove the requirement for anti-HBs levels to be >100 iu/l for acceptance of stem cell donations from donors who are anti-HBc-positive provided the HBV DNA result is negative.
- Version details:
BM-DSG Edition 203 Release 17 (31 March 2014)