Haemoglobin disorders - Bone Marrow and Peripheral Blood Stem Cell

Essential information

Obligatory

Must not donate if:

1. Thalassaemia major or intermedia.
2. Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD).
3. High affinity haemoglobin.
4. Other clinically significant structural or functional haemoglobinopathies.

Discretionary

1. Donors with traits for abnormal haemoglobin, accept. Inform transplant centre.
2. Donors with sickle cell trait – accept for bone marrow only.

Supporting information

See if relevant

• Anaemia
• Haemoglobin disorders
• Sickle cell trait
• Transfusion

Additional information

Stem cells from a donor who is heterozygous for a haemoglobin disorder may be accepted for transplant after a risk assessment by the transplant centre. There is no evidence of clinically significant sickling during PBSC collection in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC collection, so those with sickle cell trait must donate by BM only.