Cerebrovascular disease - Bone Marrow and Peripheral Blood Stem Cell

Essential information

Definition/s

Diseases of the vasculature of the brain include stroke, cerebrovascular accident (haemorrhagic or embolic), transient ischaemic attack.

Cerebral haemorrhage includes haemorrhages or haematomas that are intracerebral, subdural, subarachnoid, or epidural.

Includes

Cerebrovascular haemorrhage.

Obligatory

Must not donate.

Discretionary

If a berry aneurysm has been treated by interventional radiology, and the person has not had a stroke or suffered neurological deficit, refer to DCSO for individual risk assessment.

Supporting information

See if relevant

• Central nervous system disease

Additional information

Both embolic stroke and cerebral haemorrhage,(includes haemorrhages or haematomas that are intracerebral, subdural, subarachnoid, or epidural) may pose a risk of causing adverse events in stem cell donors. In order to reduce this risk, donors with a history of cerebrovascular disease must be excluded.

As regards cerebral haemorrhage after trauma, there is a concern that donors with previous traumatic brain injury may be at risk of further brain haemorrhage after stem cell donation. A small number of cases of cerebral haemorrhage in stem cell donors have been reported. In the few that occurred within 36 hours of donation, some of the donors had had previous traumatic brain injury (concussion).

Reason for change:

This is a new entry.

Version details:

BM-DSG Edition 203 Release 55 (18 April 2024)