Autoimmune disease - Bone Marrow and Peripheral Blood Stem Cell

Essential information

Obligatory

See: is there an entry for the condition?

1. Must not donate if:
   The donor has needed treatment to suppress the condition in the last 12 months.
2. Inform Transplant Centre if:
   Cells are from a donor that has an autoimmune disorder.

Supporting information

See if relevant

• G-CSF
• Liver disease

If treated with immunoglobulin or plasma exchange or filtration:

• Transfusion

Additional information

PBSC donors

G-CSF may cause a flare of some autoimmune diseases. The risk should be assessed by the Designated Medical Officer and discussed with the donor.

Treatment to suppress the condition may be with steroids, immunosuppressive drugs, antimetabolites, antibodies directed against parts of the immune system as well as other therapies. These will affect the donor's immune system. This may make the donor more susceptible to certain types of infection and also will make some infections more difficult to diagnose.

Autoimmune disease is caused by the body attacking itself. This is with antibodies that are in the fluid part of the blood (plasma), and with immune cells directly attacking target cells in the part/s of the body affected.

Transfusion of antibodies, or transfer of immune cells, could lead to similar damage in the people receiving them.

Reason for change:

A note and link have been added about G-CSF flare of autoimmune disease. Additional Information has been added to clarify treatment that may have been used to suppress the condition.

Version details:

BM-DSG Edition 203 Release 02 (11 December 2007)